منابع مشابه
Multidisciplinary Cancer Investigation: A New Path to Delve into the Ocean of Cancer Sciences
On behalf of the editorial and executive board members, it is my great pleasure to present the Multidisciplinary Cancer Investigation Journal. The rapid growth of medical sciences has necessitated the development of platforms to distribute and publish the results of research projects, and declare new discoveries. Among all medical disciplines, cancer is the one that involves the largest number...
متن کاملMultidisciplinary Cancer Investigation: A New Path to Delve into the Ocean of Cancer Sciences
On behalf of the editorial and executive board members, it is my great pleasure to present the Multidisciplinary Cancer Investigation Journal. The rapid growth of medical sciences has necessitated the development of platforms to distribute and publish the results of research projects, and declare new discoveries. Among all medical disciplines, cancer is the one that involves the largest number...
متن کاملMYC on the Path to Cancer
The MYC oncogene contributes to the genesis of many human cancers. Recent insights into its expression and function have led to therapeutic opportunities. MYC's activation by bromodomain proteins could be inhibited by drug-like molecules, resulting in tumor inhibition in vivo. Tumor growth can also be curbed by pharmacologically uncoupling bioenergetic pathways involving glucose or glutamine me...
متن کاملThe immune biology of microsatellite unstable cancer
Deficient DNA mismatch repair (MMR) boosts the accumulation of frameshift mutations in genes encompassing coding microsatellites (cMS). This results in the translation of proteins with mutation-induced frameshift peptides (neoantigens) rendering microsatellite-unstable (MSI) cancers highly immunogenic. MSI cancers express a defined set of neoantigens resulting from functionally relevant driver ...
متن کاملPath-following for linear systems with unstable zero dynamics
A path-following problem for linear systems with unstable zero dynamics is solved. While the original control variable steers the system output along the path, the path parameter θ is used as an additional control to stabilize zero dynamics with a feedback law which is nonlinear due to the path constraint. A sufficient condition for solvability of the path-following problem is given in terms of...
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ژورنال
عنوان ژورنال: Science
سال: 2002
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.297.5581.543